by Max Barry

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AEH RMB

WA Delegate: None.

Founder: The Founder Nation of Waites Corner

Last WA Update:

Board Activity History Admin Rank

Most Nations: 1,033rd
World Factbook Entry

AEH stands for Alternate Earth History.

It is a Serious, Realism Based, Modern Tech Role Play Region.

This is our Point of Divergence: The Great Plague of 1348-1352.

Before The Great Plague of 1348-1352, all history is as it is in Real Life.

After The Great Plague of 1348-1352, it is what we make of it.

If that interests you, check out our rules, fill out our simple application form, and when you are approved, have fun!

We ask that you submit an application within 72 HOURS of your arrival, and that once accepted, that you post within 5 days of your acceptance.

But, BE ADVISED, you will be expected to do the majority of your RPing in AEH. If you have nations in other regions, and are found to be RPing more there than here, you face banjection.



  1. 1

    Application for Annexing Land

    FactbookLegislation by Waites Corner . 10 reads.

  2. 2

    AEH World Map

    FactbookGeography by Dubnia . 264 reads.

  3. 1

    Weapons of Mass Destruction in AEH

    FactbookMiscellaneous by Alimun . 65 reads.

  4. 1

    Regional Rules on WMDs

    FactbookMiscellaneous by Alimun . 105 reads.

  5. 2

    Some Rules of Thumb for Building Things

    FactbookMiscellaneous by The east latins . 430 reads.

  6. 3

    AEH Land Claims

    FactbookGeography by Waites Corner . 729 reads.

  7. 3

    1st Global War 1915-1920

    FactbookHistory by Waites Corner . 160 reads.

  8. 3

    Regional Rules

    BulletinPolicy by Waites Corner . 340 reads.

  9. 3

    Membership Application

    BulletinPolicy by Waites Corner . 371 reads.

  10. 1

    2nd Global War 1941-1946

    FactbookHistory by Waites Corner . 123 reads.

▼ 7 More

Embassies: The Void of Limbo and New Donnach.

Tags: Featured, Human-Only, Medium, Modern Tech, Role Player, and Serious.

AEH contains 17 nations, the 1,033rd most in the world.

Today's World Census Report

The Most Armed in AEH

World Census experts took their lives into their hands in order to ascertain the average number of deadly weapons per citizen.

As a region, AEH is ranked 5,984th in the world for Most Armed.

NationWA CategoryMotto
1.The Kingdom of DubniaMoralistic Democracy“Montjoie Saint Denis!”
2.The Kingdom of KommeriaLeft-Leaning College State“Un reino bajo Dios.”
3.The Roman Empire of The Eastern LatinsInoffensive Centrist Democracy“Ense petit placidam sub libertate quietem”
4.The Confederate States of LesporaneaNew York Times Democracy“Libertad y Orden”
5.The Holy Empire of Neo BritiannaIron Fist Consumerists“ALL HAIL BRITANNIA!”
6.The Founder Nation of Waites CornerInoffensive Centrist Democracy“My Region, My Rules”
7.The Republic of YamnatFather Knows Best State“Yamnat, Complete, Together, Eternal”
8.The Empire of Far Eastern RussiaDemocratic Socialists“For Our Sacred Motherland!”
9.The United States of Greater AustriasRight-wing Utopia“Indivisibiliter ac Inseparabiliter”
10.The Republic of Neo-EgyptCorrupt Dictatorship“Freedom, Unity, Socialism”
12»

Regional Happenings

More...

AEH Regional Message Board

OOC:

Long Live the Prince Consort and God Save the Queen

Post by Abyssiopia suppressed by The Eastern Latins.

Farsiran wrote:From the Fars News Agency report of 03/27/2021:

Today, the Ministry of Justice issued 2 arrest warrants, one each for the person or persons calling themselves "Emperor Constantine XI" and "Vice Gerent Sir Benjamin Basevi". These 2 criminals are charged with being the leaders of an international terrorist organization masquerading as "The Roman Empire" and with supporting other terrorist organizations. The warrants state that if the 2 are apprehended, they are to be transported immediately to the Islamic Republic for trial.

Ministry spokesman Garsharp Mohammadi said: "We have no other choice. These 2 criminals and their vast organization are the single biggest threat to world peace and security imaginable. We urge all the other nations of the world join us in ridding the world of this menace."

Ooc:

This post is based on a story I read online about Iran issuing an arrest warrant for former U.S. President Donald Trump in July 2020. I couldn't resist. Lol

Farsiran wrote:From the Fars News Agency report of 03/27/2021:

Today, the Ministry of Justice issued 2 arrest warrants, one each for the person or persons calling themselves "Emperor Constantine XI" and "Vice Gerent Sir Benjamin Basevi". These 2 criminals are charged with being the leaders of an international terrorist organization masquerading as "The Roman Empire" and with supporting other terrorist organizations. The warrants state that if the 2 are apprehended, they are to be transported immediately to the Islamic Republic for trial.

Ministry spokesman Garsharp Mohammadi said: "We have no other choice. These 2 criminals and their vast organization are the single biggest threat to world peace and security imaginable. We urge all the other nations of the world join us in ridding the world of this menace."

Ooc:

This post is based on a story I read online about Iran issuing an arrest warrant for former U.S. President Donald Trump in July 2020. I couldn't resist. Lol

Emperor Haile Selassi II said today that "the issuing of a warrant for the arrest of a Head of State and the lawfully elected Head of Government of a free and independent nation is the most ridiculous action taken by another nation in diplomatic history. The only thing Iran accomplished by this was to make itself look foolish and immature in the eyes of the world."

The Emperor also called upon Russia and Egypt to cease funding the Eritrean separatists currently waging a guerrilla war in that part of Ethiopia. The fighting there has spilled over into the Tigray region of the country, where a group calling itself the "Tigray People's Liberation Front", or TPLF, has recently begun attacking police and military posts in that area.

Neo Britianna wrote:Novel HIV vaccine approach shows promise in “landmark” first-in-human trial

A novel vaccine approach for the prevention of HIV has shown promise in Phase I trials, reported IAVI and Scripps Research. According to the organisations, the vaccine successfully stimulated the production of the rare immune cells needed to generate antibodies against HIV in 97 percent of participants.

The vaccine is being developed to act as an immune primer, to trigger the activation of naïve B cells via a process called germline-targeting, as the first stage in a multi-step vaccine regimen to elicit the production of many different types of broadly neutralizing antibodies (bnAbs). Stimulating the production of bnAbs has been pursued as a holy grail in HIV for decades. It is hoped that these specialised blood proteins could attach to HIV surface proteins called spikes, which allow the virus to enter human cells, and disable them via a difficult-to-access regions that does not vary much from strain to strain. The vaccine, being done with help from the Southern California Medical School, is being developed to act as an immune primer, to trigger the activation of naïve B cells via a process called germline-targeting, as the first stage in a multi-step vaccine regimen to elicit the production of many different types of broadly neutralizing antibodies (bnAbs). Stimulating the production of bnAbs has been pursued as a holy grail in HIV for decades. It is hoped that these specialised blood proteins could attach to HIV surface proteins called spikes, which allow the virus to enter human cells, and disable them via a difficult-to-access regions that does not vary much from strain to strain.

“We and others postulated many years ago that in order to induce bnAbs, you must start the process by triggering the right B cells – cells that have special properties giving them potential to develop into bnAb-secreting cells,” explained Dr William Schief, a professor and immunologist at Scripps Research and executive director of vaccine design at IAVI’s Neutralizing Antibody Center, whose laboratory developed the vaccine. “In this trial, the targeted cells were only about one in a million of all naïve B cells. To get the right antibody response, we first need to prime the right B cells. The data from this trial affirms the ability of the vaccine immunogen to do this.”

Schief intends to present the results at the International AIDS Society HIV Research for Prevention (HIVR4P) when it convenes some time next month or earlier.

In the Phase I IAVI G001trial, 48 healthy adult volunteers were enrolled to receive either a placebo or two doses of the vaccine compound, eOD-GT8 60mer, along with an adjuvant developed by the GlaxoSmithKline.

One of the lead investigators on the trial, Dr Julie McElrath, senior vice president and director of Fred Hutch’s Vaccine and Infectious Disease Division, said the trial was “a landmark study in the HIV vaccine field,” adding that they had demonstrated “success in the first step of a pathway to induce broad neutralising antibodies against HIV-1.”

HIV affects more than 38 million people globally and is among the most difficult viruses to target with a vaccine, in large part because of its unusually fast mutation rate which allows it to constantly evolve and evade the immune system.

Dr Schief commented: “This study demonstrates proof of principle for a new vaccine concept for HIV, a concept that could be applied to other pathogens as well. With our many collaborators on the study team, we showed that vaccines can be designed to stimulate rare immune cells with specific properties and this targeted stimulation can be very efficient in humans. We believe this approach will be key to making an HIV vaccine and possibly important for making vaccines against other pathogens.”

The company’s said this study sets the stage for additional clinical trials that will seek to refine and extend the approach, with the long-term goal of creating a safe and effective HIV vaccine. As a next step, the collaborators are partnering with the biotechnology company Moderna to develop and test an mRNA-based vaccine that harnesses the approach to produce the same beneficial immune cells. According to the team, using mRNA technology could significantly accelerate the pace of HIV vaccine development and other possible roads of research.

This is a tremendous achievement for vaccine science as a whole,” said Dr Dennis Burton, professor and chair of the Department of Immunology and Microbiology at Scripps Research, scientific director of the IAVI Neutralizing Antibody Center and director of the NIH Consortium for HIV/AIDS Vaccine Development. “This clinical trial has shown that we can drive immune responses in predictable ways to make new and better vaccines, and not just for HIV. We believe this type of vaccine engineering can be applied more broadly, bringing about a new day in vaccinology.”

The scientists believe the same approach could also be applied to vaccines for other challenging pathogens such as influenza, dengue, Zika, hepatitis C and malaria. If such research into vaccines for those diseases bears fruit, large parts of the world will be rid of such diseases once and for all.

The research is open to the international community as are all other ongoing research efforts being conducted by Britannia as the empire believes these vaccines should be free and for the betterment of all Humanity, regardless of political stances or creed.

Empire Cable Network (ECN)

Constantinople

During an interview today on the ECN news show "Empire Newsline", Health and Social Welfare Logothete Dr. Anna St Anthony expressed the willingness of His Imperial Majesty's Government (HIMG) to both help fund and participate in the work being done by Neo Britianna in the field of HIV research.

"HIMG sees great and exciting promise in this work, and is willing to not only help fund this research, but also to join in. To that end, and with the permission of the Government of Neo Britianna of course, HIMG pledges an initial investment of 50 million Nomismas, and to send a team of our researchers in this field to Neo Britianna."

"We see this as another opportunity for the friendship between our two nations to benefit not only ourselves, but the entire world, by eventually ridding the planet of this scourge."

Dr. St Anthony concluded her remarks by saying: "And if this research can be extended into other fields, as the researchers in Neo Britianna believe it can, how many diseases that now take tens of thousands of lives every year all over the globe may be eliminated?"

Pravda has published a story that 2 delegations will be sent to Far Eastern Russia in an effort to improve relations.

The sad history of this split is well know. The Far Eastern provinces of the Empire, with the blessing and covert support, it is believed, of the Romans, broke away from the Rodina during the disastrous reign of Paul II. It chose a member of the ruling Romanov Dynasty as its Tsar, and his descendant sits on the throne in Khabarovsk today. In an even more tragic development, there was fighting in Siberia between the armed forces of the 2 nations, with Russians killing Russians, brothers killing brothers.

In a more troubling development, Far Eastern Russia has developed close ties over the years with the Roman Empire (The Eastern Latins). Just recently, in fact, its Tsar married the youngest daughter of the Roman Emperor. This closeness is seen by many observers, both in and out of the Government, to pose a great threat to the security of the Rodina, and the Government seems to be finally seeking a way to reverse this trend, with this trip by the delegations being a vital first step.

One of the last acts of Paul II before his abdication was to recognize Far Eastern Russia as an independent nation, and while this recognition was quickly revoked by his successor Michael II, it still serves as the legal basis for the recognition of this nation by other nations. Yet the fact that Far Eastern Russia government, military and social forms are almost direct copies of those of the Rodina gives hope that something may be accomplished.

The 2 delegations will be an official one from the Imperial Government, led by Deputy Prime Minister Ivan Litinov, and a private one, consisting of the Tsar's sister Grand Duchess Tatiana, who is engaged to Crown Prince Rudolf of Greater Austrias, and his cousin Princess Elena Semenov. It may be remembered that the Princess was at one time engaged to be married to "King" Fernando of Spain.

The delegations will depart in 1 week, and the hope is that some kind of defrosting of tensions between the 2 nations, especially over the matter of the Kuril Islands, can be achieved, or at least discussed. As the old saying goes: "On every journey, a first step is necessary."

Random Thoughts from The Founder:

The AEH Land Claims Factbook has been updated.

Please check your claim to make sure it is correct. Any questions, please TG me.

The Eastern Latins wrote:Empire Cable Network (ECN)

Constantinople

During an interview today on the ECN news show "Empire Newsline", Health and Social Welfare Logothete Dr. Anna St Anthony expressed the willingness of His Imperial Majesty's Government (HIMG) to both help fund and participate in the work being done by Neo Britianna in the field of HIV research.

"HIMG sees great and exciting promise in this work, and is willing to not only help fund this research, but also to join in. To that end, and with the permission of the Government of Neo Britianna of course, HIMG pledges an initial investment of 50 million Nomismas, and to send a team of our researchers in this field to Neo Britianna."

"We see this as another opportunity for the friendship between our two nations to benefit not only ourselves, but the entire world, by eventually ridding the planet of this scourge."

Dr. St Anthony concluded her remarks by saying: "And if this research can be extended into other fields, as the researchers in Neo Britianna believe it can, how many diseases that now take tens of thousands of lives every year all over the globe may be eliminated?"

The researchers at Scripps Research Center and others taking part would be more than happy to welcome the team of from the Roman Empire as it will show the world that we both seek to advance the cause of science and a healthy and long life for every man, woman and child of Earth. We hope that with out combined efforts, we shall unlock these secrets and end the scourge of HIV and many other diseases once and for all.

New research report states Nanomicelles solely made of Macromolecules could help treat Pancreatic Tumor

A recent paper report put forward by Dr. William Barker at Augusta University in Georgia, has proposed a new method for treating pancreatic tumor that involves using nanomicelles entirely made of macromolecules. Barker, working with other researchers from Texas and an international team in California reported that in eukaryotic organisms, host dense peptides (HDPs) form a part of their innate immunity. It supports the host in defending against attacks by microbes by disrupting the integrity of the cellular membrane.

Taking a cue from HDPs, the researchers designed membrane-disruptive macromolecules using the two most common structural characteristics (cationic and amphipathic) of HDPs to achieve similar membrane-disrupting function to enable efficient removal of drug-resistant cancer cells. Repeated treatment delays the onset of drug resistance, indicating the potential for overcoming the problem of cancer resistance.

Despite these benefits, membrane-disruptive macromolecules often fail to differentiate between normal and cancerous cells. It is highly difficult to find ways to make membrane-disruptive macromolecules selectively active to cancerous cells and not normal cells.

As part of this study, the team employed an acid-sensitive, membrane-disruptive micelle, called M-14K, as the model for such nanoparticles. This long-circulating nanoparticle exhibited acid-activated cytotoxicity indiscriminately to both fibroblast and cancerous cells, which is achieved by acid-activatable disruption of the integrity of the cellular membrane.

The capability of such nanoparticles to intrude into the stromal barrier and remove the sheltered cancer cells was confirmed both in vivo using mouse models bearing BxPC-3 tumors and in vitro using three-dimensional (3D) cell spheroids. Most significantly, the researchers performed animal experiments and identified considerable inhibition of the expression of extracellular matrix components, conversion of the tumor tissue into a less dense structure, and remodeling of the stroma, without fostering tumor metastasis.

Removal of cancerous cells and remodeling of stroma can be simultaneously achieved by using acid-responsive nanoparticles entirely made of membrane-disruptive macromolecules. This method could pave a new way for developing efficacious drugs that can suppress the growth and metastasis of the pancreatic tumor. Dense stromal barriers that shelter cancerous cells mainly make pancreatic tumors difficult to cure. Here, the penetration of drugs is impaired. The penetration of therapeutics is boosted by using an adjuvant before using gemcitabine for stroma remodeling. However, this extensively investigated approach might increase the risk of tumor metastasis and the resistance of tumor cells to drugs. The researchers will conduct more test into the idea before they release more data in regards future trials.

Members of the Opposition in the Imperial Reichstag continued their attacks on the Government's policies in Spain and Italy in a fiery session yesterday.

Opposition Leader Dr. Paul Muller took the Government to task, citing what he estimated is the 550,000 million Marks total that have been spent on aid to the Royalist Government in Italy, and the Nationalist government in Spai, and how that money could be better spent here in the Empire and not, as he put it "on foreign adventures and propping up shaky and feeble regimes."

Deputy Foreign Minister Johanna Neumann, speaking for the Government, reiterated the firmly held position that: "The best chance for peace in both these troubled nations are for them to have stable and democratic governments. We (the Government) firmly believe that the legitimate Royalist Government in Italy and the populist Nationalist party in Spain are such stabilizing forces. In this belief, we have not only the support of the Kaiser, but, if the latest poll may be believed, some 60% of the people of the Empire."

Minister Neumann also disputed the figure of 550 million marks cited by Dr. Muller, stating that the figure is closer to 300 million marks, and firmly stating that: "The money spent did not, in any way, detract from the funds spent on the Government's domestic agenda. Despite what the Opposition would have us think, no pensioner went uncompensated, no sick person was denied health care, no unemployed person failed to receive benefits. The nation has not fallen into chaos because of the Government's actions in Italy and Spain."

The Emperor has ordered the arrest of 17 current and former army officers on charges that they are aiding and assisting the current insurgency in Eritrea.

Many of those arrested are or were supporters of the late Emperor Menelik III and his pro Russian, pro Egyptian policies.

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